66 CYTOGENETIC STUDIES IN COUPLES WITH REPRODUCTIVE WASTAGE

Cytogenetic findings in couples with fertility problems

Background: Chromosomal aberrations can be one of the causes of fertility problems, including infertility or frequent abortions. Identification of chromosomal aberrations by clinical diagnostic techniques has been primarily performed through standard karyotyping. In this screening, the prevalence of these disorders were checking in individuals with fertility problems from west population of Ira...

Cytogenetic Investigations in Couples with Male Sterility

NLRP7 in the spectrum of reproductive wastage: rare non-synonymous variants confer genetic susceptibility to recurrent reproductive wastage.

BACKGROUND NLRP7 mutations are responsible for recurrent molar pregnancies and associated reproductive wastage. To investigate the role of NLRP7 in sporadic moles and other forms of reproductive wastage, the authors sequenced this gene in a cohort of 135 patients with at least one hydatidiform mole or three spontaneous abortions; 115 of these were new patients. METHODS/RESULTS All mutations w...

cytogenetic findings in couples who are candidates for assisted reproductive techniques

objective: the present retrospective study aims at identifying the prevalence of chromosomal abnormalities in a population of couples who are candidates for assisted reproductive techniques. materials and methods: cytogenetic analysis was performed according to the standard methods on cultured cells from the patients’ peripheral blood. the culture, was harvested after 72 hours. at least 20 meta...

cytogenetic prenatal diagnosis on 66 chorionic villus samples in iran

a total number of 66 chorionic villus samples were cytogenetically investigated. the samples consisted of 30 experimental cvs from spontaneously aborted materialand 36 from live gestations.80% of the samples were successfully grown, of the 30 cases 40% (12) and 33% (10)contained a normal female and a normal male karyotype, respectively, 3.3% (1) and3.3% (1) had abnormal karyotypes (47,xx, + 21;...